What is atovaquone?

Atovaquone (brand name Mepron®) is a drug used to treat infections caused by bacteria and protozoa (single-celled organisms that cause disease). It is often combined with other drugs to treat specific infections.

In cats, it is used ‘off label’ or ‘extra label’ in combination with azithromycin to treat cytauxzoonosis. In dogs, it is used ‘off label’ or ‘extra label’ in combination with azithromycin to treat cytauxzoonosis. It may be prescribed to treat other infections in dogs. Many drugs are commonly prescribed for off label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully, as their directions may be significantly different from those on the label.


How is atovaquone given?mepron_liquid_1

Atovaquone comes as a liquid suspension. Before using, shake the bottle gently. To help with the absorption of this drug, give with food high in fat. Your veterinarian can make recommendations on canned pet food that is high in fat to give with the medication. Measure the medication carefully.

This medication can take up to a few weeks before full effects are noted, but gradual improvements are usually appreciable.


What if I miss giving my pet the medication?

If you miss giving your pet a dose, give the next dose as soon as you remember, but if it is close to the next scheduled dose when you remember, skip the missed dose and give it at the next scheduled time. Never give your pet two doses at once or give extra doses.


Are there any potential side effects?

Side effects from atovaquone have not been reported. However, if your pet experiences persistent vomiting or diarrhea, let your veterinarian know. Any side effects that you observe should be reported to your veterinarian.

This long-acting medication may last up to 4 – 6 weeks, and may last longer in pets with kidney or liver disease.


Are there any risk factors for this medication?

Atovaquone should be avoided in pregnant females.


Are there any drug interactions I should be aware of?

No drug interactions have been established with this drug. Certain antibiotics and anti-nausea drugs can reduce the effectiveness of atovaquone. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.


Is there any monitoring that needs to be done with this medication?

No specific monitoring is necessary.


How do I store chloramphenicol?

Store atovaquone at room temperature, protected from light. Do not freeze.


What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.

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